PARTICIPANTS

Agami, Reuven

Our two main research subjects are to understand the tumorigenic process and DNA-damage pathways in humans.   more

Bernards, René

My group has focused in the past five years on functional genomic approaches to cancer.   more

Berns, Anton

My group has generated and utilizes genetically engineered mouse models to mimic human thoracic cancers (lung and mesotheliomas).   more

Bos, Johannes (Hans)

The Bos lab has a focus on understanding the molecular details of the Rap1 signaling network in integrin-mediated cell adhesion and cell-cell junction formation.   more

Burgering, Boudewijn

Our group is interested in signal transduction through the pathway consisting of the lipid kinase PI3K, the serine/threonine kinase PKB/AKT and members of the Forkhead boxO (FOXO) class of transcription factors.   more

Clevers, Hans

Our previous work has shown that upon Wnt signaling, beta-catenin associates with nuclear TCFs and contributes a trans-activation domain to the resulting bipartite transcription factor.   more

Dijke, Peter ten

Our group is interested in unraveling mechanisms by which transforming growth factor-β (TGF-β) family members elicit their multifunctional cellular effects and how perturbation in their signal transduction pathways contribute to human diseases.   more

Grosveld, Frank

Our aim is to identify and characterize the transcription factors (TFs) responsible for the differentiation of the hematopoietic stem cell to the erythroid lineage and to unravel their complex organization during blood cells differentiation.   more

Heck, Albert

The general research theme of the group of Heck at Utrecht University is to develop and implement innovative mass spectrometric methods for the more efficient and detailed characterization of proteins in relation to their biological function.   more

Hoeijmakers, Jan

Our research focuses on the role of DNA damage in cancer.   more

Lohuizen, Maarten van

My group has made important contributions on the functional analysis of epigenetic gene silencing mechanisms by Polycomb-group protein complexes, which play crucial roles in controlling development, differentiation and cell proliferation and when deregulated contribute to cancer formation.   more

Medema, René

The Medema group has been studying cell cycle checkpoints for several years, with particular emphasis on mitotic checkpoints.   more

Neefjes, Jacques

The Neefjes lab studies the control of the adaptive immune response and in particular the cell biology of antigen presentation by MHC class I and MHC class II molecules.   more

Ommen, GertJan van

My group at the Department of Human Genetics of Leiden University Medical Center has as major research interests neuromuscular and neurodegenerative diseases, aiming to elucidate the genetic background, improve early diagnosis, and develop therapy, with a focus on Duchenne and other muscular dystrophies and Huntington disease.   more

Oostra, Ben

Genetic basis of neurogenetic disorders: Our group is interested to study the genetic basis for a number of 'brain' disorders, and the (dys)function of the gene(s) involved.   more

Sixma, Titia

Development of cancer is generally due to errors that occur in cellular pathways.   more

Verrijzer, Peter

We are interested in how the expression of the eukaryotic genome is regulated.   more